The Hispanic Chamber of Commerce of Metropolitan St. Louis was incorporated on April 28, 1982. The incorporators were: Maria Elena Alonso; Manuel De La O; Michael Mahler; Jennie Ojeda; Anthony B. Ramirez; Maria Isabel Thompson; Mario Santander; B. A. Villarreal; and Luis G. Zambrana. Shortly thereafter, the Hispanic Chamber was accepted as an affiliate of the United States Hispanic Chamber of Commerce (USHCC), which currently has more than two hundred affiliates across the nation.

The Hispanic Chamber strives to support and promote Hispanic small businesses. In 2009, the organization took a major step to solidifying its role as the premier Hispanic organization in the St. Louis region when it opened a Technology & Resource Center, now called the Centene Technology Center, in the City of St. Louis.

The endeavor was made possible through an appropriation from the federal government obtained by Senator Christopher “Kit” Bond. The computers at the Technology Center were purchased with an Accelerator Grant provided by AT&T. The software for the computers was donated by the Microsoft Corporation.

Also in 2009, the Hispanic Chamber established a charitable arm, the HCC STL Foundation, which will focus on youth, workforce development, and education.